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High fibrinogen level in the blood

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High fibrinogen level in the blood
Last update: 04/05/2021

What is high fibrinogen level in the blood called?

  • Hyperfibrinogenemia

What is the normal fibrinogen level in the blood?

If you need to know which are the fibrinogen reference ranges or you require more information about the role of fibrinogen in the blood, you can visit normal fibrinogen level in the blood

What does high fibrinogen level in the blood mean?

A high level of fibrinogen in the blood (hyperfibrinogenemia) is not usually used for diagnosis. Fibrinogen increases in a transient way due to multiple underlying disorders. Fibrinogen level come back to normal range when the disorder is treated.

An increase in the fibrinogen level in the blood may be usually due to:

  • Activity of fibrinogen as an acute phase reactant protein (inflammations, tumors, burns or trauma).
  • To compensate protein loss (nephrotic syndrome).
  • Genetic disease.

Prolonged high fibrinogen level in the blood should be studied since it increases the risk of suffering a cardiovascular disorder because small intravascular blood clots may lead to heart attack or strokes.

Hyperfibrinogenemia or a high fibrinogen level in the blood means:

  • Mild hyperfibrinogenemia (400 - 600 mg/dl in adults):

    When there is a mild hyperfibrinogenemia is recommended to visit your doctor and study the possible underlying causes. It may be due to menstruation or drug interference. Therefore, it is advisable to make a new test in a few weeks to see if the values return to the normal range.

    If there are other associated cardiovascular risks (smoking, high LDL cholesterol, high systolic blood pressure, family history of heart attack, etc.), you should consider to follow a healthy lifestyle (exercise, cut down on tobacco and alcohol, etc.) because the possibility to suffer a cardiovascular disease increases.

  • Moderate hyperfibrinogenemia (600 - 700 mg in adults):

    Fibrinogen level in the blood is very high and you should visit your doctor.

    If the systolic blood pressure (high blood pressure) is also very high (above 180) the risk of suffering a stroke increases by more than 10 times. It is also dangerous very if your LDL cholesterol (bad cholesterol) is higher than normal.

    Probably, in addition to study the underlying cause, you will be prescribed some medication, for example, bezafibrate trying to reduce the fibrinogen level in the blood.

  • Severe hyperfibrinogenemia (> 700 mg/dl in adults):

    If the fibrinogen level in the blood exceeds 700 mg/dl, the probability to suffer a stroke is extremely high so you should visit your doctor as soon as possible. He probably prescribes you the appropriate medication to lower this value.

Which factors can raise the fibrinogen level in the blood?

There are some health circumstances or drugs than can raise your fibrinogen level in the blood:

  • Pregnancy
  • Menopause
  • Menstruation
  • Tobacco
  • Drugs
    • Oral Contraceptives
    • Antituberculars
      • Pyrazinamide
    • Aspirin
    • Bicalutamide
    • Statin
      • Fluvastatin
      • Lovastatin
      • Simvastatin
    • Steroids
      • Norethandrolone
      • Oxandrolone
      • Oxymetholone
    • Estrogens
      • Estropipate

Which diseases can raise your fibrinogen level in the blood?

There are different diseases why the fibrinogen level in the blood can be higher than normal:

  • Diabetes mellitus
  • Nephrotic syndrome
  • Rheumatoid arthritis
  • Tuberculosis
  • Cancer
  • Acromegaly
  • Pneumonia
  • Myocardial infarction
  • Eclampsia
  • Glomerulonephritis

What can I do to lower the fibrinogen level in the blood?

If your fibrinogen blood level is high, you must follow a healthy lifestyle. The most effective measure in the short term to reduce the fibrinogen level is to give up smoking. Exercise, weight loss and stress reduction are also helpful. Diet does not have a direct effect, but cut down on alcohol may help.

Your doctor may prescribe you fibrates (bezafibrate) to lower the values if he considers it appropriate.

Where can I find more information about fibrinogen level in the blood?

You can visit our pages about:

Which values are considered a high fibrinogen level in the blood?

The following values are considered to be above the normal range:

IMPORTANT: These levels are expressed in mg/dL. They are an example of a healthy man/woman of about 45 years old, with a balanced diet, not known disease and not taking any medication. The ranges can be different depending on the laboratory or on your personal circumstances.

Fibrinogen
Mild hyperfibrinogenemia
401 mg/dl402 mg/dl403 mg/dl404 mg/dl405 mg/dl406 mg/dl407 mg/dl408 mg/dl
409 mg/dl410 mg/dl411 mg/dl412 mg/dl413 mg/dl414 mg/dl415 mg/dl416 mg/dl
417 mg/dl418 mg/dl419 mg/dl420 mg/dl421 mg/dl422 mg/dl423 mg/dl424 mg/dl
425 mg/dl426 mg/dl427 mg/dl428 mg/dl429 mg/dl430 mg/dl431 mg/dl432 mg/dl
433 mg/dl434 mg/dl435 mg/dl436 mg/dl437 mg/dl438 mg/dl439 mg/dl440 mg/dl
441 mg/dl442 mg/dl443 mg/dl444 mg/dl445 mg/dl446 mg/dl447 mg/dl448 mg/dl
449 mg/dl450 mg/dl451 mg/dl452 mg/dl453 mg/dl454 mg/dl455 mg/dl456 mg/dl
457 mg/dl458 mg/dl459 mg/dl460 mg/dl461 mg/dl462 mg/dl463 mg/dl464 mg/dl
465 mg/dl466 mg/dl467 mg/dl468 mg/dl469 mg/dl470 mg/dl471 mg/dl472 mg/dl
473 mg/dl474 mg/dl475 mg/dl476 mg/dl477 mg/dl478 mg/dl479 mg/dl480 mg/dl
481 mg/dl482 mg/dl483 mg/dl484 mg/dl485 mg/dl486 mg/dl487 mg/dl488 mg/dl
489 mg/dl490 mg/dl491 mg/dl492 mg/dl493 mg/dl494 mg/dl495 mg/dl496 mg/dl
497 mg/dl498 mg/dl499 mg/dl500 mg/dl501 mg/dl502 mg/dl503 mg/dl504 mg/dl
505 mg/dl506 mg/dl507 mg/dl508 mg/dl509 mg/dl510 mg/dl511 mg/dl512 mg/dl
513 mg/dl514 mg/dl515 mg/dl516 mg/dl517 mg/dl518 mg/dl519 mg/dl520 mg/dl
521 mg/dl522 mg/dl523 mg/dl524 mg/dl525 mg/dl526 mg/dl527 mg/dl528 mg/dl
529 mg/dl530 mg/dl531 mg/dl532 mg/dl533 mg/dl534 mg/dl535 mg/dl536 mg/dl
537 mg/dl538 mg/dl539 mg/dl540 mg/dl541 mg/dl542 mg/dl543 mg/dl544 mg/dl
545 mg/dl546 mg/dl547 mg/dl548 mg/dl549 mg/dl550 mg/dl551 mg/dl552 mg/dl
553 mg/dl554 mg/dl555 mg/dl556 mg/dl557 mg/dl558 mg/dl559 mg/dl560 mg/dl
561 mg/dl562 mg/dl563 mg/dl564 mg/dl565 mg/dl566 mg/dl567 mg/dl568 mg/dl
569 mg/dl570 mg/dl571 mg/dl572 mg/dl573 mg/dl574 mg/dl575 mg/dl576 mg/dl
577 mg/dl578 mg/dl579 mg/dl580 mg/dl581 mg/dl582 mg/dl583 mg/dl584 mg/dl
585 mg/dl586 mg/dl587 mg/dl588 mg/dl589 mg/dl590 mg/dl591 mg/dl592 mg/dl
593 mg/dl594 mg/dl595 mg/dl596 mg/dl597 mg/dl598 mg/dl599 mg/dl600 mg/dl
Moderate hyperfibrinogenemia
601 mg/dl602 mg/dl603 mg/dl604 mg/dl605 mg/dl606 mg/dl607 mg/dl608 mg/dl
609 mg/dl610 mg/dl611 mg/dl612 mg/dl613 mg/dl614 mg/dl615 mg/dl616 mg/dl
617 mg/dl618 mg/dl619 mg/dl620 mg/dl621 mg/dl622 mg/dl623 mg/dl624 mg/dl
625 mg/dl626 mg/dl627 mg/dl628 mg/dl629 mg/dl630 mg/dl631 mg/dl632 mg/dl
633 mg/dl634 mg/dl635 mg/dl636 mg/dl637 mg/dl638 mg/dl639 mg/dl640 mg/dl
641 mg/dl642 mg/dl643 mg/dl644 mg/dl645 mg/dl646 mg/dl647 mg/dl648 mg/dl
649 mg/dl650 mg/dl651 mg/dl652 mg/dl653 mg/dl654 mg/dl655 mg/dl656 mg/dl
657 mg/dl658 mg/dl659 mg/dl660 mg/dl661 mg/dl662 mg/dl663 mg/dl664 mg/dl
665 mg/dl666 mg/dl667 mg/dl668 mg/dl669 mg/dl670 mg/dl671 mg/dl672 mg/dl
673 mg/dl674 mg/dl675 mg/dl676 mg/dl677 mg/dl678 mg/dl679 mg/dl680 mg/dl
681 mg/dl682 mg/dl683 mg/dl684 mg/dl685 mg/dl686 mg/dl687 mg/dl688 mg/dl
689 mg/dl690 mg/dl691 mg/dl692 mg/dl693 mg/dl694 mg/dl695 mg/dl696 mg/dl
697 mg/dl698 mg/dl699 mg/dl700 mg/dl    
Severe hyperfibrinogenemia
701 mg/dl702 mg/dl703 mg/dl704 mg/dl705 mg/dl706 mg/dl707 mg/dl708 mg/dl
709 mg/dl710 mg/dl711 mg/dl712 mg/dl713 mg/dl714 mg/dl715 mg/dl716 mg/dl
717 mg/dl718 mg/dl719 mg/dl720 mg/dl721 mg/dl722 mg/dl723 mg/dl724 mg/dl
725 mg/dl726 mg/dl727 mg/dl728 mg/dl729 mg/dl730 mg/dl731 mg/dl732 mg/dl
733 mg/dl734 mg/dl735 mg/dl736 mg/dl737 mg/dl738 mg/dl739 mg/dl740 mg/dl
741 mg/dl742 mg/dl743 mg/dl744 mg/dl745 mg/dl746 mg/dl747 mg/dl748 mg/dl
749 mg/dl750 mg/dl751 mg/dl752 mg/dl753 mg/dl754 mg/dl755 mg/dl756 mg/dl
757 mg/dl758 mg/dl759 mg/dl760 mg/dl761 mg/dl762 mg/dl763 mg/dl764 mg/dl
765 mg/dl766 mg/dl767 mg/dl768 mg/dl769 mg/dl770 mg/dl771 mg/dl772 mg/dl
773 mg/dl774 mg/dl775 mg/dl776 mg/dl777 mg/dl778 mg/dl779 mg/dl780 mg/dl
781 mg/dl782 mg/dl783 mg/dl784 mg/dl785 mg/dl786 mg/dl787 mg/dl788 mg/dl
789 mg/dl790 mg/dl791 mg/dl792 mg/dl793 mg/dl794 mg/dl795 mg/dl796 mg/dl
797 mg/dl798 mg/dl799 mg/dl800 mg/dl801 mg/dl802 mg/dl803 mg/dl804 mg/dl
805 mg/dl806 mg/dl807 mg/dl808 mg/dl809 mg/dl810 mg/dl811 mg/dl812 mg/dl
813 mg/dl814 mg/dl815 mg/dl816 mg/dl817 mg/dl818 mg/dl819 mg/dl820 mg/dl
821 mg/dl822 mg/dl823 mg/dl824 mg/dl825 mg/dl826 mg/dl827 mg/dl828 mg/dl
829 mg/dl830 mg/dl831 mg/dl832 mg/dl833 mg/dl834 mg/dl835 mg/dl836 mg/dl
837 mg/dl838 mg/dl839 mg/dl840 mg/dl841 mg/dl842 mg/dl843 mg/dl844 mg/dl
845 mg/dl846 mg/dl847 mg/dl848 mg/dl849 mg/dl850 mg/dl851 mg/dl852 mg/dl
853 mg/dl854 mg/dl855 mg/dl856 mg/dl857 mg/dl858 mg/dl859 mg/dl860 mg/dl
861 mg/dl862 mg/dl863 mg/dl864 mg/dl865 mg/dl866 mg/dl867 mg/dl868 mg/dl
869 mg/dl870 mg/dl871 mg/dl872 mg/dl873 mg/dl874 mg/dl875 mg/dl876 mg/dl
877 mg/dl878 mg/dl879 mg/dl880 mg/dl881 mg/dl882 mg/dl883 mg/dl884 mg/dl
885 mg/dl886 mg/dl887 mg/dl888 mg/dl889 mg/dl890 mg/dl891 mg/dl892 mg/dl
893 mg/dl894 mg/dl895 mg/dl896 mg/dl897 mg/dl898 mg/dl899 mg/dl900 mg/dl
901 mg/dl902 mg/dl903 mg/dl904 mg/dl905 mg/dl906 mg/dl907 mg/dl908 mg/dl
909 mg/dl910 mg/dl911 mg/dl912 mg/dl913 mg/dl914 mg/dl915 mg/dl916 mg/dl
917 mg/dl918 mg/dl919 mg/dl920 mg/dl921 mg/dl922 mg/dl923 mg/dl924 mg/dl
925 mg/dl926 mg/dl927 mg/dl928 mg/dl929 mg/dl930 mg/dl931 mg/dl932 mg/dl
933 mg/dl934 mg/dl935 mg/dl936 mg/dl937 mg/dl938 mg/dl939 mg/dl940 mg/dl
Medically reviewed by our Medical staff on 04/05/2021

Bibliography

  • Concise Book of Medical Laboratory Technology: Methods and Interpretations. 2nd Edition. 2015. Ramnik Sood. ISBN: 978-93-5152-333-8. Pag. 299.
  • A Manual of Laboratory and Diagnostic Test. 9th edition. Frances Fischbach. Marshall B. Dunning III. 2014. Pag 171. ISBN-10: 1451190891.
  • Common Terminology Criteria for Adverse Events (CTCAE). Version 5.0.Published: November 27, 2017. U.S. Department of health and human Services. Available on: https://ctep.cancer.gov
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  • Essentials of Medical Laboratory Practice. Constance L. Lieseke, Elizabeth A. Zeibig. 2012. ISBN: 978-0-8036-1899-2 Pag: 324.

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