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Low fibrinogen level in the blood

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Low fibrinogen level in the blood
Last update: 04/05/2021

What is low fibrinogen level in the blood called?

  • Hypofibrinogenemia

What is the normal fibrinogen level in the blood?

If you need to know which are the fibrinogen reference ranges or you require more information about the role of fibrinogen in the blood, you can visit normal fibrinogen level in the blood

What does a low fibrinogen level in the blood mean?

A low fibrinogen level in the blood (hypofibrinogenemia) expresses the difficulty to stop bleeding.

If the low level is chronic may be consequence to a deficiency in the production of fibrinogen.

  • Due to liver diseases: Cirrhosis.
  • Due to a genetic disorder that prevents the correct synthesis of fibrinogen (hypofibrinogenemia, afibrinogenemia or congenital dysfibrinogenemia).
  • Due to malnutrition.

If the decrease in the fibrinogen level appears in an acute way, it may mean an excessive consumption and suggests a problem such as DIC (disseminated intravascular coagulation) or fibrinolysis.

Hypofibrinogenemia or a low blood fibrinogen level means:

  • Mild hypofibrinogenemia (150 - 200 mg/dl in adults):

    A mild hypofibrinogenemia is not usually a matter for concern.

    Many drugs can interference fibrinogen level in the blood. Talk to your doctor and make a new test in a few months to see if values return to normal range.

  • Moderate hypofibrinogenemia (100 - 150 mg/dl in adults):

    Moderate hypofibrinogenemia requires a visit to your doctor to find out a possible disease.

    Bleeding may take longer to stop and additional coagulation test may be performed to look for the underlying cause of this decrease.

  • Marked hypofibrinogenemia (50 - 100 mg/dl in adults):

    A marked hypofibrinogenemia require medical help and in some cases hospitalization.

    It may suggest a disease called DIC (Disseminated Intravascular Coagulation) if fibrinogen values are progressively decreasing and so are platelets in the blood.

    Your doctor may prescribe you fibrinogen to raise your level to around 200 mg/dl through either fibrinogen concentrate, plasma or cryoprecipitate.

  • Severe hypofibrinogenemia (< 50 mg/dl in adults):

    A severe hypofibrinogenemia requires urgent medical help because it is necessary to increase the fibrinogen level in the blood as soon as possible.

    Sometimes it may be due to a congenital disorder such as hypofibrinogenemia with fibrinogen values between 20 and 80 mg / dl or congenital afibrinogenemia with total absence of fibrinogen (< 2 mg / dl).

Which factors can reduce the fibrinogen level in the blood?

There are some circumstances than can reduce your fibrinogen level in the blood:

  • Mushroom poisoning
  • Malnutrition
  • Blood transfusion
  • Drugs
    • Antiplatelet drug
      • Ticlopidine
    • Antineoplastics
      • Asparaginase
    • Oral Contraceptives
      • Medroxyprogesterone
    • Antiepileptic drugs
      • Valproate
      • Lamotrigine
    • Antineoplastic drugs
      • Fluorouracil
    • Beta blockers
      • Atenolol
    • Corticosteroids
      • Prednisone
    • Statin
      • Lovastatin
      • Pravastatin
      • Simvastatin
    • Anabolic steroids
      • Danazol
    • Streptokinase
    • Combination of estrogen and progesterone
    • Factor VIIa
    • Fibrate
      • Bezafibrate
      • Ciprofibrate
      • Clofibrate
      • Gemfibrozil
    • Pentoxifylline
    • Raloxifene

Which diseases can reduce your fibrinogen level in the blood?

Lower than normal level of fibrinogen in the blood can be due to the following diseases:

  • Disseminated intravascular coagulation
  • Liver failure
  • Congenital hypofibrinogenemia
  • Congenital afibrinogenemia
  • Congenital dysfibrinogenemia
  • Fibrinolysis
  • Hepatic cirrhosis

What can I do to increase the fibrinogen level in the blood?

If your fibrinogen level is low, it is important not to take anticoagulant medication to avoid prolonged bleeding.

It is also advisable not to practice contact sports such as boxing, soccer or hockey to avoid injuries and bleeding.

In case you need a supplementary supply of fibrinogen there are several possibilities using fibrinogen concentrate, plasma or cryoprecipitate.

Where can I find more information about fibrinogen level in the blood?

You can visit our pages about:

Which values are considered a low fibrinogen level in the blood?

The following values are considered to be above the normal range:

IMPORTANT: These levels are expressed in mg/dL. They are an example of a healthy man/woman of about 45 years old, with a balanced diet, not known disease and not taking any medication. The ranges can be different depending on the laboratory or on your personal circumstances.

Fibrinogen
Mild hypofibrinogenemia
199 mg/dl198 mg/dl197 mg/dl196 mg/dl195 mg/dl194 mg/dl193 mg/dl192 mg/dl
191 mg/dl190 mg/dl189 mg/dl188 mg/dl187 mg/dl186 mg/dl185 mg/dl184 mg/dl
183 mg/dl182 mg/dl181 mg/dl180 mg/dl179 mg/dl178 mg/dl177 mg/dl176 mg/dl
175 mg/dl174 mg/dl173 mg/dl172 mg/dl171 mg/dl170 mg/dl169 mg/dl168 mg/dl
167 mg/dl166 mg/dl165 mg/dl164 mg/dl163 mg/dl162 mg/dl161 mg/dl160 mg/dl
159 mg/dl158 mg/dl157 mg/dl156 mg/dl155 mg/dl154 mg/dl153 mg/dl152 mg/dl
151 mg/dl150 mg/dl      
Moderate hypofibrinogenemia
149 mg/dl148 mg/dl147 mg/dl146 mg/dl145 mg/dl144 mg/dl143 mg/dl142 mg/dl
141 mg/dl140 mg/dl139 mg/dl138 mg/dl137 mg/dl136 mg/dl135 mg/dl134 mg/dl
133 mg/dl132 mg/dl131 mg/dl130 mg/dl129 mg/dl128 mg/dl127 mg/dl126 mg/dl
125 mg/dl124 mg/dl123 mg/dl122 mg/dl121 mg/dl120 mg/dl119 mg/dl118 mg/dl
117 mg/dl116 mg/dl115 mg/dl114 mg/dl113 mg/dl112 mg/dl111 mg/dl110 mg/dl
109 mg/dl108 mg/dl107 mg/dl106 mg/dl105 mg/dl104 mg/dl103 mg/dl102 mg/dl
101 mg/dl100 mg/dl      
Marked hypofibrinogenemia
99 mg/dl98 mg/dl97 mg/dl96 mg/dl95 mg/dl94 mg/dl93 mg/dl92 mg/dl
91 mg/dl90 mg/dl89 mg/dl88 mg/dl87 mg/dl86 mg/dl85 mg/dl84 mg/dl
83 mg/dl82 mg/dl81 mg/dl80 mg/dl79 mg/dl78 mg/dl77 mg/dl76 mg/dl
75 mg/dl74 mg/dl73 mg/dl72 mg/dl71 mg/dl70 mg/dl69 mg/dl68 mg/dl
67 mg/dl66 mg/dl65 mg/dl64 mg/dl63 mg/dl62 mg/dl61 mg/dl60 mg/dl
59 mg/dl58 mg/dl57 mg/dl56 mg/dl55 mg/dl54 mg/dl53 mg/dl52 mg/dl
51 mg/dl50 mg/dl      
Severe hypofibrinogenemia
49 mg/dl48 mg/dl47 mg/dl46 mg/dl45 mg/dl44 mg/dl43 mg/dl42 mg/dl
41 mg/dl40 mg/dl39 mg/dl38 mg/dl37 mg/dl36 mg/dl35 mg/dl34 mg/dl
33 mg/dl32 mg/dl31 mg/dl30 mg/dl29 mg/dl28 mg/dl27 mg/dl26 mg/dl
25 mg/dl24 mg/dl23 mg/dl22 mg/dl21 mg/dl20 mg/dl19 mg/dl18 mg/dl
17 mg/dl16 mg/dl15 mg/dl14 mg/dl13 mg/dl12 mg/dl11 mg/dl10 mg/dl
9 mg/dl8 mg/dl7 mg/dl6 mg/dl5 mg/dl4 mg/dl3 mg/dl2 mg/dl
1 mg/dl0 mg/dl      
Medically reviewed by our Medical staff on 04/05/2021

Bibliography

  • Concise Book of Medical Laboratory Technology: Methods and Interpretations. 2nd Edition. 2015. Ramnik Sood. ISBN: 978-93-5152-333-8. Pag. 299.
  • A Manual of Laboratory and Diagnostic Test. 9th edition. Frances Fischbach. Marshall B. Dunning III. 2014. Pag 171. ISBN-10: 1451190891.
  • Common Terminology Criteria for Adverse Events (CTCAE). Version 5.0.Published: November 27, 2017. U.S. Department of health and human Services. Available on: https://ctep.cancer.gov
  • Laboratory tests and diagnostic procedures with nursing diagnoses (8th ed), Jane Vincent Corbett, Angela Denise Banks, ISBN: 978-0-13-237332-6, Pag. 321.
  • Essentials of Medical Laboratory Practice. Constance L. Lieseke, Elizabeth A. Zeibig. 2012. ISBN: 978-0-8036-1899-2 Pag: 324.

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