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High CRP level in the blood

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High CRP level in the blood
Last update: 12/05/2021

What is high C-Reactive protein CRP level in the blood called?

  • High C-Reactive Protein (CRP)

What is the normal C-Reactive protein CRP level in the blood?

If you need to know which are the C-Reactive protein reference ranges or you require more information about the role of C-Reactive protein in the blood, you can visit normal C-Reactive protein level in the blood

What does a high CRP mean?

A high C-Reactive Protein (CRP) level in the blood is usually a sign of inflammation or bacterial infection because CRP is one of the most sensitive acute-phase reactants.

Elevated serum concentration of CRP is an unequivocal evidence of an active tissue damage process, but it is a nonspecific test that indicates only an inflammation.

CRP can increase dramatically in case of severe trauma, bacterial infection, inflammation, surgery, or neoplastic proliferation.

A high CRP may be a sign of the following diseases:

  • Inflammatory bowel diseases (Crohn's disease, ulcerative colitis).
  • Pelvic inflammatory disease.
  • Chronic inflammatory diseases (lupus, rheumatoid arthritis, vasculitis).
  • Bacterial infections (tuberculosis, bacterial meningitis, pneumonia).

Since CRP production is a non-specific response to tissue injury, it is recommended that results of the test should be correlated with clinical findings to arrive at the final diagnosis.

A high CRP value in a blood test means:

  • Mild CRP increase (1 - 3 mg/dl in adult men, 1.6 - 3 in adult women):

    A mild CRP increase is suggestive of an inflammatory process or disease.

    It may be due to an inflammatory bowel disease (Crohn's disease, ulcerative colitis) or a chronic inflammatory disease such as rheumatoid arthritis.

    There is also some medication such as hormone replacement therapy for menopause that may increase CRP in the blood.

  • Moderate CRP increase (3 - 10 mg/dl in adults):

    A moderate CRP increase may be a sign of a low-grade inflammation due to inflammatory disease or bacterial infection.

    It may be a consequence of suffering rheumatoid arthritis. A value up to 5 mg/dl is related to a mild inflammation and around 10 mg/dl to a severe inflammation.

    In women, it may be due to Pelvic inflammatory disease.

    Another possibility is a bacterial infection such as tuberculosis or rheumatic fever.

  • Severe CRP increase (> 10 mg/dl in adults):

    A severe CRP increase suggests an acute inflammation due to bacterial infections. Infections, most often bacterial, were found in approximately 80 percent of patients with values of CRP in excess of 10 mg/dl.

    CRP values can be above 50 mg/dl and go up to 100 mg/dl. In this case, the possibility to suffer a bacterial infection is greater (over 90%).

    It may be due to suffering from bacterial meningitis, bacterial pneumonia or purulent bronchitis.

Which factors can raise the CRP in a blood test?

There are some health circumstances or drugs than can raise your CRP level in the blood:

  • Obesity
  • Surgical Intervention
  • Burns
  • Tobacco
  • Kidney transplantation
  • Injury
  • Drugs
    • Oral Contraceptives
      • Estrogens

Which diseases can raise your CRP in a blood test?

The most common diseases why the CRP rate can be higher than normal are:

  • Rheumatoid arthritis
  • Reiter's syndrome
  • Crohn's disease
  • Ulcerative colitis
  • Diverticulitis
  • Pelvic inflammatory disease
  • Lupus
  • Vasculitis
  • Myocardial infarction
  • Bacterial meningitis
  • Tuberculosis
  • Rheumatic fever
  • Pneumonia
  • Kidney failure
  • Pyelonephritis
  • Osteomyelitis
  • Polymyalgia rheumatica
  • Temporal arteritis
  • Sepsis

What can I do to lower the CRP?

To lower the CRP level in the blood it is necessary to treat the underlying inflammatory process that is causing the increase.

Some tips may also help you to reduce CRP level:

  • Do regular exercise (cycling, walking, etc.).
  • Lose weight and follow a balanced diet.
  • Avoid stress.
  • Give up smoking.

Where can I find more information about CRP level in the blood?

You can visit our pages about:

Which values are considered a high CRP level in the blood?

The following values are considered to be above the normal range:

IMPORTANT: These levels are expressed in mg/dl. They are an example of a healthy man of about 40 years old with no known disease and not taking any medication. The ranges can be different depending on the laboratory or on your personal circumstances.

C-Reactive protein
Mild CRP increase
1.1 mg/dl1.2 mg/dl1.3 mg/dl1.4 mg/dl1.5 mg/dl1.6 mg/dl1.7 mg/dl1.8 mg/dl
1.9 mg/dl2 mg/dl2.1 mg/dl2.2 mg/dl2.3 mg/dl2.4 mg/dl2.5 mg/dl2.6 mg/dl
2.7 mg/dl2.8 mg/dl2.9 mg/dl3 mg/dl    
Moderate CRP increase
3.1 mg/dl3.2 mg/dl3.3 mg/dl3.4 mg/dl3.5 mg/dl3.6 mg/dl3.7 mg/dl3.8 mg/dl
3.9 mg/dl4 mg/dl4.1 mg/dl4.2 mg/dl4.3 mg/dl4.4 mg/dl4.5 mg/dl4.6 mg/dl
4.7 mg/dl4.8 mg/dl4.9 mg/dl5 mg/dl5.1 mg/dl5.2 mg/dl5.3 mg/dl5.4 mg/dl
5.5 mg/dl5.6 mg/dl5.7 mg/dl5.8 mg/dl5.9 mg/dl6 mg/dl6.1 mg/dl6.2 mg/dl
6.3 mg/dl6.4 mg/dl6.5 mg/dl6.6 mg/dl6.7 mg/dl6.8 mg/dl6.9 mg/dl7 mg/dl
7.1 mg/dl7.2 mg/dl7.3 mg/dl7.4 mg/dl7.5 mg/dl7.6 mg/dl7.7 mg/dl7.8 mg/dl
7.9 mg/dl8 mg/dl8.1 mg/dl8.2 mg/dl8.3 mg/dl8.4 mg/dl8.5 mg/dl8.6 mg/dl
8.7 mg/dl8.8 mg/dl8.9 mg/dl9 mg/dl9.1 mg/dl9.2 mg/dl9.3 mg/dl9.4 mg/dl
9.5 mg/dl9.6 mg/dl9.7 mg/dl9.8 mg/dl9.9 mg/dl10 mg/dl  
Severe CRP increase
10.1 mg/dl10.2 mg/dl10.3 mg/dl10.4 mg/dl10.5 mg/dl10.6 mg/dl10.7 mg/dl10.8 mg/dl
10.9 mg/dl11 mg/dl11.1 mg/dl11.2 mg/dl11.3 mg/dl11.4 mg/dl11.5 mg/dl11.6 mg/dl
11.7 mg/dl11.8 mg/dl11.9 mg/dl12 mg/dl12.1 mg/dl12.2 mg/dl12.3 mg/dl12.4 mg/dl
12.5 mg/dl12.6 mg/dl12.7 mg/dl12.8 mg/dl12.9 mg/dl13 mg/dl13.1 mg/dl13.2 mg/dl
13.3 mg/dl13.4 mg/dl13.5 mg/dl13.6 mg/dl13.7 mg/dl13.8 mg/dl13.9 mg/dl14 mg/dl
14.1 mg/dl14.2 mg/dl14.3 mg/dl14.4 mg/dl14.5 mg/dl14.6 mg/dl14.7 mg/dl14.8 mg/dl
14.9 mg/dl15 mg/dl15.1 mg/dl15.2 mg/dl15.3 mg/dl15.4 mg/dl15.5 mg/dl15.6 mg/dl
15.7 mg/dl15.8 mg/dl15.9 mg/dl16 mg/dl16.1 mg/dl16.2 mg/dl16.3 mg/dl16.4 mg/dl
16.5 mg/dl16.6 mg/dl16.7 mg/dl16.8 mg/dl16.9 mg/dl17 mg/dl17.1 mg/dl17.2 mg/dl
17.3 mg/dl17.4 mg/dl17.5 mg/dl17.6 mg/dl17.7 mg/dl17.8 mg/dl17.9 mg/dl18 mg/dl
18.1 mg/dl18.2 mg/dl18.3 mg/dl18.4 mg/dl18.5 mg/dl18.6 mg/dl18.7 mg/dl18.8 mg/dl
18.9 mg/dl19 mg/dl19.1 mg/dl19.2 mg/dl19.3 mg/dl19.4 mg/dl19.5 mg/dl19.6 mg/dl
19.7 mg/dl19.8 mg/dl19.9 mg/dl20 mg/dl20.1 mg/dl20.2 mg/dl20.3 mg/dl20.4 mg/dl
20.5 mg/dl20.6 mg/dl20.7 mg/dl20.8 mg/dl20.9 mg/dl21 mg/dl21.1 mg/dl21.2 mg/dl
21.3 mg/dl21.4 mg/dl21.5 mg/dl21.6 mg/dl21.7 mg/dl21.8 mg/dl21.9 mg/dl22 mg/dl
22.1 mg/dl22.2 mg/dl22.3 mg/dl22.4 mg/dl22.5 mg/dl22.6 mg/dl22.7 mg/dl22.8 mg/dl
22.9 mg/dl23 mg/dl23.1 mg/dl23.2 mg/dl23.3 mg/dl23.4 mg/dl23.5 mg/dl23.6 mg/dl
23.7 mg/dl23.8 mg/dl23.9 mg/dl24 mg/dl24.1 mg/dl24.2 mg/dl24.3 mg/dl24.4 mg/dl
24.5 mg/dl24.6 mg/dl24.7 mg/dl24.8 mg/dl24.9 mg/dl25 mg/dl25.1 mg/dl25.2 mg/dl
25.3 mg/dl25.4 mg/dl25.5 mg/dl25.6 mg/dl25.7 mg/dl25.8 mg/dl25.9 mg/dl26 mg/dl
26.1 mg/dl26.2 mg/dl26.3 mg/dl26.4 mg/dl26.5 mg/dl26.6 mg/dl26.7 mg/dl26.8 mg/dl
26.9 mg/dl27 mg/dl27.1 mg/dl27.2 mg/dl27.3 mg/dl27.4 mg/dl27.5 mg/dl27.6 mg/dl
27.7 mg/dl27.8 mg/dl27.9 mg/dl28 mg/dl28.1 mg/dl28.2 mg/dl28.3 mg/dl28.4 mg/dl
28.5 mg/dl28.6 mg/dl28.7 mg/dl28.8 mg/dl28.9 mg/dl29 mg/dl29.1 mg/dl29.2 mg/dl
29.3 mg/dl29.4 mg/dl29.5 mg/dl29.6 mg/dl29.7 mg/dl29.8 mg/dl29.9 mg/dl30 mg/dl
30.1 mg/dl30.2 mg/dl30.3 mg/dl30.4 mg/dl30.5 mg/dl30.6 mg/dl30.7 mg/dl30.8 mg/dl
30.9 mg/dl31 mg/dl31.1 mg/dl31.2 mg/dl31.3 mg/dl31.4 mg/dl31.5 mg/dl31.6 mg/dl
31.7 mg/dl31.8 mg/dl31.9 mg/dl32 mg/dl32.1 mg/dl32.2 mg/dl32.3 mg/dl32.4 mg/dl
32.5 mg/dl32.6 mg/dl32.7 mg/dl32.8 mg/dl32.9 mg/dl33 mg/dl33.1 mg/dl33.2 mg/dl
33.3 mg/dl33.4 mg/dl33.5 mg/dl33.6 mg/dl33.7 mg/dl33.8 mg/dl33.9 mg/dl34 mg/dl
34.1 mg/dl34.2 mg/dl34.3 mg/dl34.4 mg/dl34.5 mg/dl34.6 mg/dl34.7 mg/dl34.8 mg/dl
34.9 mg/dl35 mg/dl35.1 mg/dl35.2 mg/dl35.3 mg/dl35.4 mg/dl35.5 mg/dl35.6 mg/dl
35.7 mg/dl35.8 mg/dl35.9 mg/dl36 mg/dl36.1 mg/dl36.2 mg/dl36.3 mg/dl36.4 mg/dl
36.5 mg/dl36.6 mg/dl36.7 mg/dl36.8 mg/dl36.9 mg/dl37 mg/dl37.1 mg/dl37.2 mg/dl
37.3 mg/dl37.4 mg/dl37.5 mg/dl37.6 mg/dl37.7 mg/dl37.8 mg/dl37.9 mg/dl38 mg/dl
38.1 mg/dl38.2 mg/dl38.3 mg/dl38.4 mg/dl38.5 mg/dl38.6 mg/dl38.7 mg/dl38.8 mg/dl
38.9 mg/dl39 mg/dl39.1 mg/dl39.2 mg/dl39.3 mg/dl39.4 mg/dl39.5 mg/dl39.6 mg/dl
39.7 mg/dl39.8 mg/dl39.9 mg/dl40 mg/dl40.1 mg/dl40.2 mg/dl40.3 mg/dl40.4 mg/dl
40.5 mg/dl40.6 mg/dl40.7 mg/dl40.8 mg/dl40.9 mg/dl41 mg/dl41.1 mg/dl41.2 mg/dl
41.3 mg/dl41.4 mg/dl41.5 mg/dl41.6 mg/dl41.7 mg/dl41.8 mg/dl41.9 mg/dl42 mg/dl
42.1 mg/dl42.2 mg/dl42.3 mg/dl42.4 mg/dl42.5 mg/dl42.6 mg/dl42.7 mg/dl42.8 mg/dl
42.9 mg/dl43 mg/dl43.1 mg/dl43.2 mg/dl43.3 mg/dl43.4 mg/dl43.5 mg/dl43.6 mg/dl
43.7 mg/dl43.8 mg/dl43.9 mg/dl44 mg/dl44.1 mg/dl44.2 mg/dl44.3 mg/dl44.4 mg/dl
44.5 mg/dl44.6 mg/dl44.7 mg/dl44.8 mg/dl44.9 mg/dl45 mg/dl45.1 mg/dl45.2 mg/dl
45.3 mg/dl45.4 mg/dl45.5 mg/dl45.6 mg/dl45.7 mg/dl45.8 mg/dl45.9 mg/dl46 mg/dl
46.1 mg/dl46.2 mg/dl46.3 mg/dl46.4 mg/dl46.5 mg/dl46.6 mg/dl46.7 mg/dl46.8 mg/dl
46.9 mg/dl47 mg/dl47.1 mg/dl47.2 mg/dl47.3 mg/dl47.4 mg/dl47.5 mg/dl47.6 mg/dl
47.7 mg/dl47.8 mg/dl47.9 mg/dl48 mg/dl48.1 mg/dl48.2 mg/dl48.3 mg/dl48.4 mg/dl
48.5 mg/dl48.6 mg/dl48.7 mg/dl48.8 mg/dl48.9 mg/dl49 mg/dl49.1 mg/dl49.2 mg/dl
49.3 mg/dl49.4 mg/dl49.5 mg/dl49.6 mg/dl49.7 mg/dl49.8 mg/dl49.9 mg/dl50 mg/dl
50.1 mg/dl50.2 mg/dl50.3 mg/dl50.4 mg/dl50.5 mg/dl50.6 mg/dl50.7 mg/dl50.8 mg/dl
50.9 mg/dl51 mg/dl51.1 mg/dl51.2 mg/dl51.3 mg/dl51.4 mg/dl51.5 mg/dl51.6 mg/dl
51.7 mg/dl51.8 mg/dl51.9 mg/dl52 mg/dl52.1 mg/dl52.2 mg/dl52.3 mg/dl52.4 mg/dl
52.5 mg/dl52.6 mg/dl52.7 mg/dl52.8 mg/dl52.9 mg/dl53 mg/dl53.1 mg/dl53.2 mg/dl
53.3 mg/dl53.4 mg/dl53.5 mg/dl53.6 mg/dl53.7 mg/dl53.8 mg/dl53.9 mg/dl54 mg/dl
54.1 mg/dl54.2 mg/dl54.3 mg/dl54.4 mg/dl54.5 mg/dl54.6 mg/dl54.7 mg/dl54.8 mg/dl
Medically reviewed by our Medical staff on 12/05/2021

Bibliography

  • Concise Book of Medical Laboratory Technology: Methods and Interpretations. 2nd Edition. 2015. Ramnik Sood. ISBN: 978-93-5152-333-8. Pag. 650.
  • A Manual of Laboratory and Diagnostic Test. 9th edition. Frances Fischbach. Marshall B. Dunning III. 2014. Pag 624. ISBN-10: 1451190891.
  • Laboratory tests and diagnostic procedures with nursing diagnoses (8th ed), Jane Vincent Corbett, Angela Denise Banks, ISBN: 978-0-13-237332-6, Pag. 365.
  • UptoDate: Acute phase reactants. Irving Kushner. Available on: https://www.uptodate.com

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