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Low lipase level in the blood

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Low lipase level in the blood
Last update: 22/12/2021

What is low lipase level in the blood called?

  • Hypolipasemia

What is the normal level of lipase in the blood?

If you need to know which are the lipase reference ranges or you require more information about lipase in a blood test, you can visit normal lipase in a blood test.

What does a low lipase level in the blood mean?

The lipase present in the blood comes from the pancreas. The lipase blood test is usually performed to detect only high levels.

Therefore, a low level of lipase in the blood is rare and it is not used as a diagnostic tool. In many labs, low values of lipase in the blood, even close to 0 U/l are considered to be in the normal range.

However, a low value of lipase in the blood may be a sign of a pancreatic disorder because the pancreas is unable to produce enough amount of lipase, for example, in case of suffering from cystic fibrosis.

Lipase blood values are usually given in U/L but sometimes you can see those values in ukat/l following the International System of Units (SI). In case your values are in ukat/l you can convert them using this tool:

ukat/l
  • Mild hypolipasemia (0 - 31 U/l in adults below 60 years old):

    A mild hypolipasemia has no diagnostic meaning. Some labs may consider values near zero U/L in the in the normal range, so it is not usually a matter for concern.

Which factors can reduce the lipase level in the blood?

Some drugs may reduce the lipase in the blood:

  • Drugs
    • Nonsteroidal anti-inflammatory drugs (NSAIDs)
      • Mesalazine
    • Antineoplastics
      • Hydroxycarbamide
    • Growth inhibitor hormone
      • Somatostatin
    • Protamine sulfate

Which diseases can reduce your lipase level in the blood?

The following diseases can explain a lipase level in the blood lower than normal:

  • Cystic fibrosis

    What can I do to increase the lipase level in the blood?

    It is not necessary to take any measure trying to increase the lipase blood level because a low value has no clinical meaning.

    Where can I find more information about lipase level in the blood?

    You can visit our pages about:

    Which values are considered a low lipase level in the blood?

    The following values are considered to be above the normal range:

    IMPORTANT: These levels are expressed in U/L. They are an example of a healthy man of about 45 years old with no known disease and not taking any medication. The ranges can be different depending on the laboratory or on your personal circumstances.

    Lipase
    Mild hypolipasemia
    30 U/l29 U/l28 U/l27 U/l26 U/l25 U/l24 U/l23 U/l
    22 U/l21 U/l20 U/l19 U/l18 U/l17 U/l16 U/l15 U/l
    14 U/l13 U/l12 U/l11 U/l10 U/l9 U/l8 U/l7 U/l
    6 U/l5 U/l4 U/l3 U/l2 U/l1 U/l0 U/l 
    Medically reviewed by our Medical staff on 22/12/2021

    Bibliography

    • Concise Book of Medical Laboratory Technology: Methods and Interpretations. 2nd Edition. 2015. Ramnik Sood. ISBN: 978-93-5152-333-8. Pag. 520.
    • Tietz. Fundamentals of Clinical Chemistry. Carl A. Burtis, Edward R. Ashwood, David E. Bruns, Barbara G. Sawyer. WB Saunders Company, 2008. Pag 332. ISBN: 978-0-7216-3865-2.
    • A Manual of Laboratory and Diagnostic Test. 9th edition. Frances Fischbach. Marshall B. Dunning III. 2014. Pag 407. ISBN-10: 1451190891.
    • Common Terminology Criteria for Adverse Events (CTCAE). Version 5.0.Published: November 27, 2017. U.S. Department of health and human Services. Available on: https://ctep.cancer.gov

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