Blood test

High lipase level in the blood

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High lipase level in the blood
Last update: 22/12/2021

What is high lipase level in the blood called?

  • Hyperlipasemia

What is the normal level of lipase in the blood?

If you need to know which are the lipase reference ranges or you require more information about lipase in a blood test, you can visit normal lipase in a blood test.

What does high lipase level in the blood mean?

If your doctor has decided to perform the lipase blood test is in order to find a pancreatic disorder.

A high value of lipase in the blood is suggestive of acute pancreatitis that may be followed by abdominal pain, but it may be due also to:

  • Other pancreatic disorders (obstruction of the pancreatic duct, pancreatic cancer, etc.).
  • Gallbladder disorder (cholecystitis, biliary obstruction, etc.).
  • Diabetic ketoacidosis (25% of people with diabetic ketoacidosis have a high lipase level in the blood).
  • Kidney failure.
  • Drugs: Some drugs may elevate lipase level (narcotics, cholinergic agents, heparin, etc.).

Lipase blood values are usually given in U/L but sometimes you can see those values in ukat/l following the International System of Units (SI). In case your values are in ukat/l you can convert them using this tool:

ukat/l
  • Mild hyperlipasemia (186 - 280 U/l in adults below 60 years old):

    A mild hyperlipasemia may suggest a pancreatic disorder, although it may be due also to other causes, such as kidney or gallbladder problems, ulcers, diabetic ketoacidosis, etc.

    In addition, lipase level fluctuates throughout the day. For that reason, it is important to measure the lipase level in successive tests to confirm a real hyperlipasemia.

    Some drugs may elevate the level of lipase in the blood. If you are taking any kind of medication, please tell your doctor about it.

  • Moderate hyperlipasemia (280 - 400 U/l in adults below 60 years old):

    A moderate hyperlipasemia usually requires additional tests, such as a CT scan of the pancreas, to confirm or rule out a pancreatic disorder. The CT scan is more recommended when abdominal pain is present.

  • Marked hyperlipasemia (400 - 900 U/l in adults below 60 years old):

    A marked hyperlipasemia must be studied carefully.

    It is probable that you experience abdominal pain or discomfort due to a pancreatic disorder.

    If the lipase level in the blood is three times over the upper limit, the probability to be related to an acute pancreatitis is about 98%.

  • Severe hyperlipasemia (> 900 U/l in adults below 60 years old):

    A severe hyperlipasemia is usually due to an acute pancreatitis or some type of pancreatic disorder.

Which factors can raise the lipase level in the blood?

There are some procedures or drugs than can raise your lipase level in the blood:

  • Endoscopic retrograde cholangiopancreatography
  • X-ray
  • Drugs
    • Nonsteroidal anti-inflammatory drugs (NSAIDs)
      • Indomethacin
    • Antibacterial
      • Sulfafurazole
    • Antibiotics
      • Metronidazole
    • Antineoplastics
      • Pegaspargase
    • Anticoagulants
      • Heparin
    • Oral Contraceptives
    • Antiepileptic drugs
      • Valproate
    • Antiretrovirals
      • Zalcitabine
    • Cholinergic
      • Bethanechol
    • Corticosteroids
      • Methylprednisolone
    • Diuretics
      • Furosemide
      • Thiazides
    • Estrogens
    • Adrenocorticotropic hormone
    • Methacholine
    • Opiate
      • Codeine
      • Pentazocine
    • Secretin
    • Triprolidine + pseudoephedrine

Which diseases can raise your lipase level in the blood?

High values of lipase in the blood can be a sign of the following diseases:

What can I do to lower the lipase level in the blood?

The best way to lower the lipase blood level is by treating the underlying causes.

If you are taking any medication, ask your doctor because there are many drugs that may interfere with the lipase blood level.

Where can I find more information about lipase in a blood test?

You can visit our pages about:

Which values are considered a high lipase in a blood test?

The following values are considered to be above the normal range:

IMPORTANT: These levels are expressed in U/L. They are an example of a healthy man of about 45 years old with no known disease and not taking any medication. The ranges can be different depending on the laboratory or on your personal circumstances.

Lipase
Mild hyperlipasemia
187 U/l188 U/l189 U/l190 U/l191 U/l192 U/l193 U/l194 U/l
195 U/l196 U/l197 U/l198 U/l199 U/l200 U/l201 U/l202 U/l
203 U/l204 U/l205 U/l206 U/l207 U/l208 U/l209 U/l210 U/l
211 U/l212 U/l213 U/l214 U/l215 U/l216 U/l217 U/l218 U/l
219 U/l220 U/l221 U/l222 U/l223 U/l224 U/l225 U/l226 U/l
227 U/l228 U/l229 U/l230 U/l231 U/l232 U/l233 U/l234 U/l
235 U/l236 U/l237 U/l238 U/l239 U/l240 U/l241 U/l242 U/l
243 U/l244 U/l245 U/l246 U/l247 U/l248 U/l249 U/l250 U/l
251 U/l252 U/l253 U/l254 U/l255 U/l256 U/l257 U/l258 U/l
259 U/l260 U/l261 U/l262 U/l263 U/l264 U/l265 U/l266 U/l
267 U/l268 U/l269 U/l270 U/l271 U/l272 U/l273 U/l274 U/l
275 U/l276 U/l277 U/l278 U/l279 U/l280 U/l  
Moderate hyperlipasemia
281 U/l282 U/l283 U/l284 U/l285 U/l286 U/l287 U/l288 U/l
289 U/l290 U/l291 U/l292 U/l293 U/l294 U/l295 U/l296 U/l
297 U/l298 U/l299 U/l300 U/l301 U/l302 U/l303 U/l304 U/l
305 U/l306 U/l307 U/l308 U/l309 U/l310 U/l311 U/l312 U/l
313 U/l314 U/l315 U/l316 U/l317 U/l318 U/l319 U/l320 U/l
321 U/l322 U/l323 U/l324 U/l325 U/l326 U/l327 U/l328 U/l
329 U/l330 U/l331 U/l332 U/l333 U/l334 U/l335 U/l336 U/l
337 U/l338 U/l339 U/l340 U/l341 U/l342 U/l343 U/l344 U/l
345 U/l346 U/l347 U/l348 U/l349 U/l350 U/l351 U/l352 U/l
353 U/l354 U/l355 U/l356 U/l357 U/l358 U/l359 U/l360 U/l
361 U/l362 U/l363 U/l364 U/l365 U/l366 U/l367 U/l368 U/l
369 U/l370 U/l371 U/l372 U/l373 U/l374 U/l375 U/l376 U/l
377 U/l378 U/l379 U/l380 U/l381 U/l382 U/l383 U/l384 U/l
385 U/l386 U/l387 U/l388 U/l389 U/l390 U/l391 U/l392 U/l
393 U/l394 U/l395 U/l396 U/l397 U/l398 U/l399 U/l400 U/l
Marked hyperlipasemia
401 U/l402 U/l403 U/l404 U/l405 U/l406 U/l407 U/l408 U/l
409 U/l410 U/l411 U/l412 U/l413 U/l414 U/l415 U/l416 U/l
417 U/l418 U/l419 U/l420 U/l421 U/l422 U/l423 U/l424 U/l
425 U/l426 U/l427 U/l428 U/l429 U/l430 U/l431 U/l432 U/l
433 U/l434 U/l435 U/l436 U/l437 U/l438 U/l439 U/l440 U/l
441 U/l442 U/l443 U/l444 U/l445 U/l446 U/l447 U/l448 U/l
449 U/l450 U/l451 U/l452 U/l453 U/l454 U/l455 U/l456 U/l
457 U/l458 U/l459 U/l460 U/l461 U/l462 U/l463 U/l464 U/l
465 U/l466 U/l467 U/l468 U/l469 U/l470 U/l471 U/l472 U/l
473 U/l474 U/l475 U/l476 U/l477 U/l478 U/l479 U/l480 U/l
481 U/l482 U/l483 U/l484 U/l485 U/l486 U/l487 U/l488 U/l
489 U/l490 U/l491 U/l492 U/l493 U/l494 U/l495 U/l496 U/l
497 U/l498 U/l499 U/l500 U/l501 U/l502 U/l503 U/l504 U/l
505 U/l506 U/l507 U/l508 U/l509 U/l510 U/l511 U/l512 U/l
513 U/l514 U/l515 U/l516 U/l517 U/l518 U/l519 U/l520 U/l
521 U/l522 U/l523 U/l524 U/l525 U/l526 U/l527 U/l528 U/l
529 U/l530 U/l531 U/l532 U/l533 U/l534 U/l535 U/l536 U/l
537 U/l538 U/l539 U/l540 U/l541 U/l542 U/l543 U/l544 U/l
545 U/l546 U/l547 U/l548 U/l549 U/l550 U/l551 U/l552 U/l
553 U/l554 U/l555 U/l556 U/l557 U/l558 U/l559 U/l560 U/l
561 U/l562 U/l563 U/l564 U/l565 U/l566 U/l567 U/l568 U/l
569 U/l570 U/l571 U/l572 U/l573 U/l574 U/l575 U/l576 U/l
577 U/l578 U/l579 U/l580 U/l581 U/l582 U/l583 U/l584 U/l
585 U/l586 U/l587 U/l588 U/l589 U/l590 U/l591 U/l592 U/l
593 U/l594 U/l595 U/l596 U/l597 U/l598 U/l599 U/l600 U/l
601 U/l602 U/l603 U/l604 U/l605 U/l606 U/l607 U/l608 U/l
609 U/l610 U/l611 U/l612 U/l613 U/l614 U/l615 U/l616 U/l
617 U/l618 U/l619 U/l620 U/l621 U/l622 U/l623 U/l624 U/l
625 U/l626 U/l627 U/l628 U/l629 U/l630 U/l631 U/l632 U/l
633 U/l634 U/l635 U/l636 U/l637 U/l638 U/l639 U/l640 U/l
641 U/l642 U/l643 U/l644 U/l645 U/l646 U/l647 U/l648 U/l
649 U/l650 U/l651 U/l652 U/l653 U/l654 U/l655 U/l656 U/l
657 U/l658 U/l659 U/l660 U/l661 U/l662 U/l663 U/l664 U/l
665 U/l666 U/l667 U/l668 U/l669 U/l670 U/l671 U/l672 U/l
673 U/l674 U/l675 U/l676 U/l677 U/l678 U/l679 U/l680 U/l
681 U/l682 U/l683 U/l684 U/l685 U/l686 U/l687 U/l688 U/l
689 U/l690 U/l691 U/l692 U/l693 U/l694 U/l695 U/l696 U/l
697 U/l698 U/l699 U/l700 U/l701 U/l702 U/l703 U/l704 U/l
705 U/l706 U/l707 U/l708 U/l709 U/l710 U/l711 U/l712 U/l
713 U/l714 U/l715 U/l716 U/l717 U/l718 U/l719 U/l720 U/l
721 U/l722 U/l723 U/l724 U/l725 U/l726 U/l727 U/l728 U/l
Medically reviewed by our Medical staff on 22/12/2021

Bibliography

  • Concise Book of Medical Laboratory Technology: Methods and Interpretations. 2nd Edition. 2015. Ramnik Sood. ISBN: 978-93-5152-333-8. Pag. 520.
  • Tietz. Fundamentals of Clinical Chemistry. Carl A. Burtis, Edward R. Ashwood, David E. Bruns, Barbara G. Sawyer. WB Saunders Company, 2008. Pag 332. ISBN: 978-0-7216-3865-2.
  • A Manual of Laboratory and Diagnostic Test. 9th edition. Frances Fischbach. Marshall B. Dunning III. 2014. Pag 407. ISBN-10: 1451190891.
  • Common Terminology Criteria for Adverse Events (CTCAE). Version 5.0.Published: November 27, 2017. U.S. Department of health and human Services. Available on: https://ctep.cancer.gov

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