Last update: 18/11/2020

- What is high level of cholinesterase in the blood called?
- What is the normal cholinesterase level in the blood?
- What does a high cholinesterase level in the blood mean?
- Which factors can raise the cholinesterase level in the blood?
- Which diseases can raise your cholinesterase level in the blood?
- What can I do to lower the cholinesterase level in the blood?
- Which values are considered a high cholinesterase level in the blood?

- Cholinesterase high

If you need to know which are the cholinesterase reference ranges or you require more information about the role of cholinesterase in the blood you can visit: Normal cholinesterase level in the blood

A high level of cholinesterase in the blood is called hypercholinesterasemia and it may be related with multiple diseases and disorders such as hyperlipidemia (too many lipids or fats in the blood), diabetes patients with obesity, anxiety, mental disorders or by interference with antiepileptic drugs. A marked high value of cholinesterase may be related to nephrotic syndrome.

A high cholinesterase blood level means:

- Moderate cholinesterase increase (> 18 U/ml in adults):
A high level of cholinesterase in the blood may be a consequence of diabetes with obesity, thyrotoxicosis, schizophrenia, hypertension, mood disorders or after a concussion.

If cholinesterase levels are very high, the most probable cause is due to nephrotic syndrome.

Warning: Normal range may differ from lab to lab depending of the type of cholinesterase measured, the sample, the technique or the substrate used to measure it. It is very important to check the normal range that appears in your report.

There are some health circumstances or drugs than can raise your cholinesterase level in the blood:

- Anxiety
- Obesity
- Drugs
- Antiepileptic drugs
- Valproate
- Carbamazepine
- Phenytoin
- Phenobarbital

- Antiepileptic drugs

A cholinesterase level higher than normal may be a sign of the following diseases:

- Diabetes mellitus
- Nephrotic syndrome
- Reticulosis
- Protein-losing enteropathy

- Thyrotoxicosis
- Fatty liver
- Schizophrenia
- Hyperthyroidism

If your cholinesterase level in the blood is a bit high, you can try to act on the possible causes such as obesity, diabetes or a high cholesterol level in the blood. Besides, if you are taking antiepileptic drugs you can ask your doctor because it may interfere with your cholinesterase level in the blood.

There is a group of medicines, called acetylcholinesterase inhibitors (pyridostigmine, neostigmine), that may reduce the cholinesterase level in the blood. Nowadays they are used to treat myasthenia gravis or Alzheimer. An excessive dose may provoke a cholinergic crisis.

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The following values are considered to be above the normal range:

**IMPORTANT:** These levels are expressed in U/ml. They are an example of a healthy man of about 45 years old with no known disease and not taking any medication. The ranges can be different depending on the laboratory or on your personal circumstances.

Cholinesterase | |||||||
---|---|---|---|---|---|---|---|

Moderate cholinesterase increase | |||||||

18.1 U/ml | 18.2 U/ml | 18.3 U/ml | 18.4 U/ml | 18.5 U/ml | 18.6 U/ml | 18.7 U/ml | 18.8 U/ml |

18.9 U/ml | 19 U/ml | 19.1 U/ml | 19.2 U/ml | 19.3 U/ml | 19.4 U/ml | 19.5 U/ml | 19.6 U/ml |

19.7 U/ml | 19.8 U/ml | 19.9 U/ml | 20 U/ml | 20.1 U/ml | 20.2 U/ml | 20.3 U/ml | 20.4 U/ml |

20.5 U/ml | 20.6 U/ml | 20.7 U/ml | 20.8 U/ml | 20.9 U/ml | 21 U/ml | 21.1 U/ml | 21.2 U/ml |

21.3 U/ml | 21.4 U/ml | 21.5 U/ml | 21.6 U/ml | 21.7 U/ml | 21.8 U/ml | 21.9 U/ml | 22 U/ml |

22.1 U/ml | 22.2 U/ml | 22.3 U/ml | 22.4 U/ml | 22.5 U/ml | 22.6 U/ml | 22.7 U/ml | 22.8 U/ml |

22.9 U/ml | 23 U/ml | 23.1 U/ml | 23.2 U/ml | 23.3 U/ml | 23.4 U/ml | 23.5 U/ml | 23.6 U/ml |

23.7 U/ml | 23.8 U/ml | 23.9 U/ml | 24 U/ml | 24.1 U/ml | 24.2 U/ml | 24.3 U/ml | 24.4 U/ml |

24.5 U/ml | 24.6 U/ml | 24.7 U/ml | 24.8 U/ml | 24.9 U/ml | 25 U/ml | 25.1 U/ml | 25.2 U/ml |

25.3 U/ml | 25.4 U/ml | 25.5 U/ml | 25.6 U/ml | 25.7 U/ml | 25.8 U/ml | 25.9 U/ml | 26 U/ml |

26.1 U/ml | 26.2 U/ml | 26.3 U/ml | 26.4 U/ml | 26.5 U/ml | 26.6 U/ml | 26.7 U/ml | 26.8 U/ml |

26.9 U/ml | 27 U/ml | 27.1 U/ml | 27.2 U/ml | 27.3 U/ml | 27.4 U/ml | 27.5 U/ml | 27.6 U/ml |

27.7 U/ml | 27.8 U/ml | 27.9 U/ml | 28 U/ml | 28.1 U/ml | 28.2 U/ml | 28.3 U/ml | 28.4 U/ml |

28.5 U/ml | 28.6 U/ml | 28.7 U/ml | 28.8 U/ml | 28.9 U/ml | 29 U/ml | 29.1 U/ml | 29.2 U/ml |

29.3 U/ml | 29.4 U/ml | 29.5 U/ml | 29.6 U/ml | 29.7 U/ml | 29.8 U/ml | 29.9 U/ml | 30 U/ml |

30.1 U/ml | 30.2 U/ml | 30.3 U/ml | 30.4 U/ml | 30.5 U/ml | 30.6 U/ml | 30.7 U/ml | 30.8 U/ml |

30.9 U/ml | 31 U/ml | 31.1 U/ml | 31.2 U/ml | 31.3 U/ml | 31.4 U/ml | 31.5 U/ml | 31.6 U/ml |

31.7 U/ml | 31.8 U/ml | 31.9 U/ml | 32 U/ml | 32.1 U/ml | 32.2 U/ml | 32.3 U/ml | 32.4 U/ml |

32.5 U/ml | 32.6 U/ml | 32.7 U/ml | 32.8 U/ml | 32.9 U/ml | 33 U/ml | 33.1 U/ml | 33.2 U/ml |

33.3 U/ml | 33.4 U/ml | 33.5 U/ml | 33.6 U/ml | 33.7 U/ml | 33.8 U/ml | 33.9 U/ml | 34 U/ml |

34.1 U/ml | 34.2 U/ml | 34.3 U/ml | 34.4 U/ml | 34.5 U/ml | 34.6 U/ml | 34.7 U/ml | 34.8 U/ml |

34.9 U/ml | 35 U/ml | 35.1 U/ml | 35.2 U/ml | 35.3 U/ml | 35.4 U/ml | 35.5 U/ml | 35.6 U/ml |

35.7 U/ml | 35.8 U/ml | 35.9 U/ml | 36 U/ml | 36.1 U/ml | 36.2 U/ml | 36.3 U/ml | 36.4 U/ml |

36.5 U/ml | 36.6 U/ml | 36.7 U/ml | 36.8 U/ml | 36.9 U/ml | 37 U/ml | 37.1 U/ml | 37.2 U/ml |

37.3 U/ml | 37.4 U/ml | 37.5 U/ml | 37.6 U/ml | 37.7 U/ml | 37.8 U/ml | 37.9 U/ml | 38 U/ml |

38.1 U/ml | 38.2 U/ml | 38.3 U/ml | 38.4 U/ml | 38.5 U/ml | 38.6 U/ml | 38.7 U/ml | 38.8 U/ml |

38.9 U/ml | 39 U/ml | 39.1 U/ml | 39.2 U/ml | 39.3 U/ml | 39.4 U/ml | 39.5 U/ml | 39.6 U/ml |

39.7 U/ml | 39.8 U/ml | 39.9 U/ml | 40 U/ml |

- Tietz. Fundamentals of Clinical Chemistry. Carl A. Burtis, Edward R. Ashwood, David E. Bruns, Barbara G. Sawyer. WB Saunders Company, 2008. Pag 328. ISBN: 978-0-7216-3865-2.