Fatty liver disease is the accumulation of excessive amounts of triglycerides and other types of fats inside liver cells.
The liver is the organ responsible to transform ingested fats into other types of fats that can be stored and used later.
In fatty liver disease, large droplets of fat containing mostly triglycerides are stored in the liver and thus the liver increases in size.
Fatty liver is not a worrying condition by itself, but if not treated properly, it may lead to other diseases. It is estimated that 15% of people with fatty liver disease may have cirrhosis in the next 15 years.
Fatty liver disease can be a temporary or a long-term condition. It is reversible when the underlying cause is diagnosed and treated.
Normally, fatty liver disease may go unnoticed since it is not painful. On the other hand, in severe cases, the liver can increase three times its normal size and be painful.
The most common cause of fatty liver is alcoholism. When the amount of alcohol consumed is high, the liver changes the way it breaks down and stores fats.
Other conditions that may cause fatty liver disease are:
Fatty liver disease can affect more than a third of adults in Western countries and 10% of children or adolescents.
During pregnancy, the disease has an approximate incidence of 5 cases per 100,000 pregnancies and is more common in case of twin pregnancy or when the mother is underweight.
Often, fatty liver does not show any symptoms. If they are present, the most frequent symptoms are:
In case of fatty liver during pregnancy, it is frequent to suffer:
Fatty liver may be suspected during a physical examination by noticing that the liver is enlarged and tender. It can be confirmed with a liver biopsy, where a small sample of liver tissue is removed with a needle through a small incision.
In a blood test, people with fatty liver disease usually have high levels of SGOT (AST) and SGPT (ALT) transaminases. In many cases, the alkaline phosphatase (ALP) is also elevated as a consequence of cholestasis (decreased flow of bile from the liver to the duodenum).
Treatment for fatty liver is focused on correcting the underlying cause and providing supportive care.
General measures, such as losing weight and do regular exercise are helpful in people with obesity.
If alcoholism is the main cause, alcohol consumption should be stopped. Following a healthy and balanced diet is also recommended.
If fatty liver occurs during pregnancy, it is advisable to deliver the baby as soon as the appropriate conditions are met.