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Low uric acid level in the blood

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Low uric acid level in the blood

What is low uric acid level in the blood called?

  • Hypouricemia

What is the normal uric acid level in the blood?

If you need to know which are the uric acid reference ranges or you require more information about the role of uric acid in the blood you can visit: Normal uric acid level in the blood

What does a low uric acid level in the blood mean?

A low level of uric acid in the blood is usually due to:

  • A kidney disorder that causes an excessive excretion of uric acid in the urine.
  • A vegetarian diet or with a low-purine intake.

Uric acid values are usually given in mg/dl but sometimes you can see those values in nmol/l following the International System of Units (SI). In case your values are in nmol/l you can convert them using this tool:

µmol/l
  • Mild hypouricemia (2 - 3.5 mg/dl adult men and 2 - 2.6 mg/dl in adult women):

    The uric acid level in the blood is a bit low but not a matter for concern. Maybe your diet is unbalanced for example a vegetarian diet low consumption of purines.

    You should eat more food rich in purines to check if your values return to normal range in a future blood test. Otherwise, additional screening test should be performed.

  • Marked hypouricemia (< <2 mg/dL in adults):

    Your acid uric level is extremely low.

    It can be seen in case of an unbalanced diet with an important deficit of purines, molybdenum or folic acid.

    If you follow a balanced diet, it may suggest a genetic disorder that blocks the purine absorption or its transformation in uric acid. You should visit your doctor to study a possible hereditary metabolic disorder such as Fanconi syndrome or Wilson’s disease.

Which factors can reduce the uric acid level in the blood?

There are some circumstances than can reduce your uric acid level in the blood:

  • Folate deficiency
  • Molybdenum deficiency
  • Purine deficiency
  • Drugs
    • Nonsteroidal anti-inflammatory drugs (NSAIDs)
      • Indomethacin
    • Anticoagulants
      • Warfarin
    • Antipsychotics
      • Chlorpromazine
    • High dose aspirin theraphy (more than 3 g/day)
    • Corticosteroids
    • Adrenocorticotropic hormone
    • Female hormones
    • Sevelamer
    • Uricosuric
      • Allopurinol
      • Probenecid

Which diseases can reduce your uric acid level in the blood?

Lower than normal level of uric acid in the blood can be due to:

  • Fanconi syndrome
  • Wilson's disease
  • Syndrome of inappropriate antidiuretic hormone secretion
  • Hereditary xanthinuria

What can I do to increase the uric acid level in the blood?

A low level of uric acid in the blood can be a consequence of an unbalanced diet, for example a vegetarian diet with a low meat consumption of beef and pork. This can cause a deficit of purine intake.

To increase the purine intake, so they can be transformed into uric acid, it is possible to eat some vegetables, legumes and fish rich in purines. For example:

  • Vegetables: Asparagus, spinach or mushrooms
  • Legumes: Beans or lentils
  • Fish: Sardines or trout

It is also important the water intake. An excessive water intake can increase the excretion of uric acid in the urine.

Finally, is advisable to eat food rich in molybdenum such as liver, lentils, beans or peas.

Where can I find more information about uric acid level in the blood?

You can visit our pages about:

Which values are considered a low uric acid level in the blood?

The following values are considered to be below the normal range:

IMPORTANT: These levels are expressed in mg/dl They are an example of a healthy man of about 45 years old with no known disease and not taking any medication. The ranges can be different depending on the laboratory or on your personal circumstances.

Uric acid
Status
Mild hypouricemia
3.4 mg/dl3.3 mg/dl3.2 mg/dl3.1 mg/dl3 mg/dl2.9 mg/dl2.8 mg/dl2.7 mg/dl
2.6 mg/dl2.5 mg/dl2.4 mg/dl2.3 mg/dl2.2 mg/dl2.1 mg/dl2 mg/dl 
Marked hypouricemia
1.9 mg/dl1.8 mg/dl1.7 mg/dl1.6 mg/dl1.5 mg/dl1.4 mg/dl1.3 mg/dl1.2 mg/dl
1.1 mg/dl1 mg/dl0.9 mg/dl0.8 mg/dl0.7 mg/dl0.6 mg/dl0.5 mg/dl0.4 mg/dl
0.3 mg/dl0.2 mg/dl0.1 mg/dl0 mg/dl    
foto de Dr. Javier Muga Bustamante
Written by

Dr. Javier Muga Bustamante

Last update: 06/04/2020

Bibliography

  • Concise Book of Medical Laboratory Technology: Methods and Interpretations. 2nd Edition. 2015. Ramnik Sood. ISBN: 978-93-5152-333-8. Pag. 492.
  • Painter PC, Cope JY, Smith JL. Reference information for the clinical laboratory. In: Burtis CA, Ashwood ER, eds. Tietz textbook of clinical chemistry. Philadelphia: WB Saunders Company, 1999;1838pp. ISBN 9780721656106.
  • Thomas L. Uric acid. In: Thomas L, Hrsg. Labor und Diagnose. Indikation und Bewertung von Laborbefunden für die medizinische Diagnostik. Frankfurt/Main: TH-Books Verlagsgesellschaft, 2005:280-289.
  • Common Terminology Criteria for Adverse Events (CTCAE). Version 5.0.Published: November 27, 2017. U.S. Department of health and human Services. Disponible en: https://ctep.cancer.gov

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