Blood test

Low alkaline phosphatase (ALP) level in the blood

Blood test
>
Low alkaline phosphatase (ALP) level in the blood

What is low alkaline phosphatase (ALP) level in the blood called?

  • Hypophosphatasemia

What is the normal alkaline phosphatase (ALP) level in the blood?

If you need to know which are the alkaline phosphatase (ALP) reference ranges or you require more information about the role of alkaline phosphatase (ALP) in the blood you can visit: Normal alkaline phosphatase (ALP) level in the blood

What does a low alkaline phosphatase (ALP) level in the blood mean?

Low alkaline phosphatase (ALP) in the blood is not common. It may be a consequence of a disease but the most usual reason is a low-protein diet or a zinc deficiency. If it occurs in children or adolescents is a matter of concern because it can cause growth disorders.

  • Mild Hypophosphatasemia (< 30 U/l in adult men and < 17 U/l in adult women):

    Mild hypophosphatasemia may be a consequence of a vegetarian diet with deficiency of proteins or zinc.

    A vitamin C deficit (like occurs in scurvy) can lower the alkaline phosphatase (ALP) level in the blood. In the developed countries is not common to find this deficiency.

    Hypothyroidism can be also a possibility. A visit to your doctor is advisable. He will study your medical record and he will decide if a thyroid function test is necessary. TSH level in the blood can be a help.

Which factors can reduce the alkaline phosphatase (ALP) level in the blood?

To suffer a particular health situation can reduce your alkaline phosphatase (ALP) level in the blood:

  • Low-protein diet
  • Zinc deficiency
  • Malnutrition
  • Drugs
    • Oral Contraceptives
    • Antiestrogens
      • Tamoxifen
    • Corticosteroids
      • Prednisone

Which diseases can reduce your alkaline phosphatase (ALP) level in the blood?

The following diseases can explain an alkaline phosphatase (ALP) level in the blood lower than normal:

  • Hypothyroidism
  • Congenital hypothyroidism
  • Scurvy
  • Achondroplasia
  • Wilson's disease
  • Pernicious anemia
  • Celiac disease

What can I do to increase the alkaline phosphatase (ALP) level in the blood?

If your alkaline phosphatase level is slightly low you must follow a balanced diet with an adequate intake of zinc.

Food rich in zinc includes:

  • Seafood
  • Oysters and clams
  • Lamb meat
  • Beef meat

Where can I find more information about alkaline phosphatase (ALP) level in the blood?

You can visit our pages about:

Which values are considered a low alkaline phosphatase (ALP) level in the blood?

The following values are considered to be below the normal range:

IMPORTANT: These levels are expressed in U/L. They are an example of a healthy man of about 45 years old with no known disease and not taking any medication. The ranges can be different depending on the laboratory or on your personal circumstances.

Normal ranges of alkaline phosphatase (ALP) in the blood in children and in pregnancy are very different at the values presented here. In that case you must use the respective reference tables.

Alkaline phosphatase
Moderate hypophosphatasemia
29 U/L28 U/L27 U/L26 U/L25 U/L24 U/L23 U/L22 U/L
21 U/L20 U/L19 U/L18 U/L17 U/L16 U/L15 U/L14 U/L
13 U/L12 U/L11 U/L10 U/L9 U/L8 U/L7 U/L6 U/L
5 U/L4 U/L3 U/L2 U/L1 U/L0 U/L  
foto de Dr. Javier Muga Bustamante
Written by

Dr. Javier Muga Bustamante

Last update: 03/04/2020

Bibliography

  • Concise Book of Medical Laboratory Technology: Methods and Interpretations. 2nd Edition. 2015. Ramnik Sood. ISBN: 978-93-5152-333-8. Pag. 523.
  • Moss DW, Henderson RA. Clinical Enzymology. In: Burtis CA, Ashwood ER, eds. Tietz textbook of clinical chemistry. Philadelphia:WB Saunders Company, 1999; 676-684. ISBN 9780721656106.
  • Tietz NW, Rinker D, Shaw LM. IFCC methods for the measurement of catalytic concentration of enzymes Part 5. IFCC method for alkaline phosphatase. J Clin Chem Clin Biochem 1983;21:731-48.
  • Common Terminology Criteria for Adverse Events (CTCAE). Version 5.0.Published: November 27, 2017. U.S. Department of health and human Services. Disponible en: https://ctep.cancer.gov
  • Severity grading in drug induced liver injury. U.S. National Library of Medicine. Disponible en: https://livertox.nih.gov

Show more

Rating Overview

Share your thoughts about this content
Poor
Excellent

E-mail (Optional):
Add a review